Exacerbations are frequently not reported by patients2
EXPERIENCE THE DANGER
After one exacerbation* a patient’s lung function may never recover1
EXPERIENCE THE DANGER
*Moderate or severe exacerbation.
Exacerbations may increase the risk of death6,7
EXPERIENCE THE DANGER
Your COPD patients are at risk for exacerbations, even if they’ve never had one before1
~50% of patients who had an exacerbation this year did not have one in the previous 12 months.8
The more lung function a COPD patient has, the more that patient has to lose1
Even a single severe exacerbation accelerates and worsens total lung function decline by ~4.5x in patients with mild COPD.1
Don’t let risk become reality
The irreversible damage that comes with each moderate or severe exacerbation leaves your patients at a greater risk of mortality.1,6,7
Median survival of patients who were hospitalized for their first severe exacerbation6
References: 1. Dransfield MT, Kunisaki KM, Strand MJ, et al. Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;195(3):324-330. 2. Leidy NK, Murray LT, Jones P, Sethi S. Performance of the EXAcerbations of Chronic Pulmonary Disease Tool patient-reported outcome measure in three clinical trials of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(3):316-325. 3. Aaron SD, Donaldson GC, Whitmore GA, Hurst JR, Ramsay T, Wedzicha JA. Time course and pattern of COPD exacerbation onset. Thorax. 2012;67(3):238-243. 4. Avoiding COPD Exacerbations and Pneumonia. COPD Foundation Web site. https://www.copdfoundation.org/Learn-More/I-am-a-Person-with-COPD/Avoiding-Exacerbations-and-Pneumonia.aspx. Accessed May 26, 2020. 5. Data on File, REF-67225, AstraZeneca Pharmaceuticals LP. 6. Suissa S, Dell'Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67(11):957-963. 7. Rothnie KJ, Müllerová H, Smeeth L, Quint JK. Natural history of chronic obstructive pulmonary disease exacerbations in a general practice–based population with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(4):464-471. 8. Müllerová H, Shukla A, Hawkins A, Quint J. Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study. BMJ Open. 2014;4:e006171. doi:10.1136/bmjopen-2014-006171.