Your COPD patients are at risk for exacerbations, even if they’ve never had one before1

~50% of patients who had an exacerbation this year did not have one in the previous 12 months.8

50% of Exacerbation Patients
50% of Exacerbation Patients

EXPERIENCE THE DANGER

The more lung function a COPD patient has, the more that patient has to lose1

Even a single severe exacerbation accelerates and worsens total lung function decline by ~4.5x in patients with mild COPD.1

Average Annual Change in FEV Line Graph
Average Annual Change in FEV Line Graph

Don’t let risk become reality

The irreversible damage that comes with each moderate or severe exacerbation leaves your patients at a greater risk of mortality.1,6,7

Median Survival of 3.6 Years
Median Survival of 3.6 Years

Median survival of patients who were hospitalized for their first severe exacerbation6

References: 1. Dransfield MT, Kunisaki KM, Strand MJ, et al. Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;195(3):324-330. 2. Leidy NK, Murray LT, Jones P, Sethi S. Performance of the EXAcerbations of Chronic Pulmonary Disease Tool patient-reported outcome measure in three clinical trials of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014;11(3):316-325. 3. Aaron SD, Donaldson GC, Whitmore GA, Hurst JR, Ramsay T, Wedzicha JA. Time course and pattern of COPD exacerbation onset. Thorax. 2012;67(3):238-243. 4. Avoiding COPD Exacerbations and Pneumonia. COPD Foundation Web site. https://www.copdfoundation.org/Learn-More/I-am-a-Person-with-COPD/Avoiding-Exacerbations-and-Pneumonia.aspx. Accessed May 26, 2020. 5. Data on File, REF-67225, AstraZeneca Pharmaceuticals LP. 6. Suissa S, Dell'Aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax. 2012;67(11):957-963. 7. Rothnie KJ, Müllerová H, Smeeth L, Quint JK. Natural history of chronic obstructive pulmonary disease exacerbations in a general practice–based population with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(4):464-471. 8. Müllerová H, Shukla A, Hawkins A, Quint J. Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study. BMJ Open. 2014;4:e006171. doi:10.1136/bmjopen-2014-006171.